Inhibition of cGMP-metabolizing PDEs as target for cognitive enhancement
نویسندگان
چکیده
منابع مشابه
PDEs-Based Method for Image Enhancement
Removing noise from data is often the first step in data analysis. De-noising technique should not be only reduce the noise, but do so without blurring or changing the location of the edges. Many approaches have been proposed to accomplish this; in this paper, we have compared three recently developed techniques for image enhancement and denoising. These methods are based on the use of partial ...
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The nitric oxide (NO)-cGMP pathway has been implicated as playing a crucial role in the induction of cerebellar long-term depression (LTD). The amplitude and duration of the cGMP signal is controlled by cyclic nucleotide phosphodiesterases (PDEs). Here we identify PDE5 and PDE1B as the two major cGMP-hydrolyzing PDEs specifically and differentially expressed in the Purkinje neurons of mouse cer...
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Current suggestions for capacities that should be targeted for moral enhancement has centered on traits like empathy, fairness or aggression. The literature, however, lacks a proper model for understanding the interplay and complexity of moral capacities, which limits the practicability of proposed interventions. In this paper, I integrate some existing knowledge on the nature of human moral be...
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ژورنال
عنوان ژورنال: BMC Pharmacology and Toxicology
سال: 2015
ISSN: 2050-6511
DOI: 10.1186/2050-6511-16-s1-a19